What is human chimera?

A chimera is an organism whose cells are derived from two or more zygotes. Recipients of tissue and organ transplants are artificial chimeras. Two zygotes can fuse together during an early embryonic stage to form a fusion chimera. Most chimeras remain undetected, especially if both zygotes are of the same genetic sex.

What are chimeras used for?

Chimeras are incredibly useful for understanding how animals grow and develop. They might one day be used to grow life-saving organs that can be transplanted into humans.

What is a chimera mouse?

A chimeric mouse contains both normal cells and genetically manipulated “knockout” cells. Coat color can reflect this with a spotted pattern. A chimeric mouse is a patchwork of normal cells and genetically manipulated “knockout” cells.

What is plant chimera?

Chimera, also spelled Chimaera, in botany, a plant or plant part that is a mixture of two or more genetically different types of cells.

How do you make chimeras?

The two most common methods of producing chimeric mice from ES cells are by the injection of cells into the blastocoel cavity of a blastocyststage host embryo6,10 or by the aggregation of ES cells with a morula-stage host embryo6,11.

What is chimerism testing?

Chimerism testing (engraftment analysis) is performed for patients who have received a hematopoietic stem cell transplant. The test involves identifying the genetic profiles of the recipient and of the donor and then evaluating the extent of mixture in the recipient’s blood or bone marrow.

What does mixed chimerism mean?

“Mixed chimerism” refers to a state in which the lymphohematopoietic system of the recipient of allogeneic hematopoietic stem cells comprises a mixture of host and donor cells. This state is usually attained through either bone marrow or mobilized peripheral blood stem cell transplantation.

What is hematopoietic chimerism?

Abstract. Mixed hematopoietic chimerism is a state in which bone marrow hematopoietic stem cells from two genetically different animals coexist.